The Chemistry/BMB Department welcomes the Lynn Lecture guest speaker Phan Truong. He will be giving a lecture titled: "Bio-inspired Metal Chemistry: How to Move Electrons and Protons."
Enzymes containing nickel can destroy reactive oxygen species (ROS) that are toxic to the cell, produce hydrogen gas, and build useful products from CO2. The majority of these Ni-enzymes are found in anaerobic organisms. However, Ni-containing superoxide dismutase (NiSOD) surprisingly still works in aerobes. Construction of synthetic models will allow us to understand how NiSOD works and inspire the development of synthetic air-stable Ni catalysts. In this presentation, I will discuss the preparation of synthetic model complexes of the Ni active site in NiSOD to find out how the enzyme uses electron transfer to detoxify the cell. In addition, I will briefly discuss treating a platinum complex with acid to study proton tunneling.
Tuesday, March 19 at 11:00am to 12:00pm
Tomsich Hall, 101
200 North College Road, Gambier, OH 43022